… what is perhaps our basic search: to find something that can kill intense pain without causing addiction. »Results have not been encouraging. We seem up against a dilemma built into Nature, much like the Heisenberg situation. There is nearly complete parallelism between analgesia and addiction. The more pain it takes away, the more we desire it. It appears we can’t have one property without the other …«
(Thomas Pynchon, Gravity’s Rainbow, New York 1973, S. 349).